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The Efficacy of Azathiorpine in Relapsing-Remitting Multiple Sclerosis Neurol 41:20-25, Goodkin,D.E.,et al, 1991 See this aricle in Pubmed Article Abstract We randomized 59 patients with relapsing-remitting multiple sclerosis to receive azathioprine(AZA)3.0 mg/kg daily or placebo in a double-masked therapeutic trial.Analysis of data for predetermined primary outcome measures demonstrated a significant difference favoring AZA for observed mean exacerbation rate after 2 years of therapy and time to deterioration in both Ambulation Index and Kurtzke Expanded Disability Status Scale score.This study confirms a modest therapeutic benefit for azathiorpine previously reported by other investigators.

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